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Figure 2 | Genome Medicine

Figure 2

From: Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach

Figure 2

The amino acid mutation spectrum in the pocket regions across 21 cancer types. (A) The missense mutation spectrum of 20 amino acids in the pocket regions across 21 cancer types. (B) The detailed three-dimensional (3D) structures showing critical pocket mutations in three genes (APOBEC3G, AKT1, and HRAS). The PDB files were downloaded from the PDB database (http://www.rcsb.org/, accessed on 1 February 2014), and 3D pictures were prepared using software PyMOL (http://www.pymol.org/). (C) The missense mutation spectrum of 20 amino acids in the pocket regions of the top 10 frequently mutated genes.

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