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Figure 3 | Genome Medicine

Figure 3

From: Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach

Figure 3

The enrichment analyses of genes harboring pocket mutations in cancer genes and a co-expressed protein interaction network (CePIN). (A) Venn diagram of genes harboring pocket mutations, cancer driver genes, and Cancer Gene Census (CGC) genes. (B) Genes harboring pocket mutations were enriched in cancer driver genes. (C) Genes harboring pocket mutations were enriched in CGC genes. (D) Genes harboring pocket mutations were enriched in cancer-associated genes. (E) Genes harboring pocket mutations tended to be highly co-expressed in CePIN. The P value was calculated using Fisher’s exact test. The detailed data regarding statistical analysis are provided in Additional file 4: Table S3 and Additional file 5: Table S4.

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