Response of the subnetwork genes to ATRA treatment. (A) mRNA expression profiles of a time-course experiment in NB4 cell lines after ATRA administration are reported; values are relative to the time of drug administration (0 h), empty symbols indicate genes that are up-regulated in APL, filled symbols genes that are down-regulated. Reversal of APL-specific dysregulation is observed for four genes: IGFBP2 and MMP2 show decreased expression whereas ITGB2 and HMOX1 show decreased expression upon ATRA treatment. (B) Overall behavior of the whole subnetwork (APL down-regulated transcripts in blue, APL up-regulated transcripts in red), observed 72 hours after treatment, highlights a general inversion of APL dysregulation. FC, fold change.