Figure 2

Number of genes differentially expressed in endocardial vegetations from (A) nondiabetic and (B) diabetic rats. Absolute number of genes down- (left) or upregulated (right) in endocardial vegetations compared with in vitro exponential (red bars), stationary (blue bars), or both growth phases (black bars). The four groups with the highest number of genes more highly expressed in vivo were amino acid transport and metabolism; carbohydrate transport and metabolism; virulence or immune evasion; and transcription, translation, and posttranslational modification.