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Table 1 List of selected genes differentially expressed in diabetic and nondiabetic vegetations

From: Staphylococcus aureusgene expression in a rat model of infective endocarditis

Gene

Diabetic versus nondiabetic

Gene product

Functional group

acpS

2.6

holo-(acyl-carrier-protein) synthase

Lipid transport and metabolism

alr

2.9

alanine racemase

Cell wall/membrane biogenesis

argG

10.0

argininosuccinate synthase

Amino acid transport and metabolism

argH

15.3

argininosuccinate lyase

Amino acid transport and metabolism

atpA

3.8

ATP synthase F1, alpha subunit

Energy production and conversion

atpE

2.4

ATP synthase F0, C subunit

Energy production and conversion

atpH

3.3

ATP synthase F1, delta subunit

Energy production and conversion

cap5F

2.5

capsular polysaccharide biosynthesis

Cell wall/membrane biogenesis

cap5K

3.5

capsular polysaccharide biosynthesis

Cell wall/membrane biogenesis

ccrB

2.0

cassette chromosome recombinase B

 

dnaE

2.6

DNA polymerase III, alpha subunit

Nucleotide metabolism, replication, recombination

fabD

3.3

malonyl CoA-acyl carrier protein transacylase

Lipid transport and metabolism

gapA

4.4

glyceraldehyde 3-P dehydrogenase

Carbohydrate transport and metabolism

geh

2.3

glycerol ester hydrolase

Miscellaneous

glpP

2.2

glycerol uptake operon regulatory protein

Transcription, translation and post-translational modification

glyS

4.2

glycyl-tRNA synthetase

Transcription, translation and post-translational modification

hemX

2.2

hemX protein

Transcription, translation and post-translational mod.

infB

2.6

translation initiation factor IF-2

Transcription, translation and post-translational modification

kdpE

2.4

DNA-binding response regulator

Regulatory

ligA

2.3

DNA ligase, NAD-dependent

Nucleotide metabolism, replication, recombination

menD

2.1

carboxylic acid synthase

Coenzyme transport and metabolism

moeA

3.4

molybdopterin biosynthesis, putative

Coenzyme transport and metabolism

nrdF

2.7

ribonucleoside-diphosphate reductase 2

Nucleotide metabolism, replication, recombination

pls

3.7

plasmin-sensitive protein

Virulence

recQ

2.8

ATP-dependent DNA helicase

Nucleotide metabolism, replication, recombination

rexA

3.2

exonuclease

Nucleotide metabolism, replication, recombination

ribD

2.7

riboflavin biosynthesis protein

Coenzyme transport and metabolism

ribE

2.4

riboflavin synthase, alpha subunit

Coenzyme transport and metabolism

ruvB

2.2

Holliday junction DNA helicase

Nucleotide metabolism, replication, recombination

sasA

4.8

LPXTG cell wall surface protein

Virulence

sirC

3.1

iron ABC transporter, permease protein

Inorganic ion transport and metabolism

ureC

7.5

urease, alpha subunit

Amino acid transport and metabolism