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Figure 5 | Genome Medicine

Figure 5

From: Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis

Figure 5

Protein-protein interaction networks of CF-related miRNA. A total of 7 CF regulated miRNAs were used to predict gene targets by employing a total of 10 different algorithms. This defined 263 putative targets which were mapped to the STRING database version 9.1 and revealed 247 PPI among 138 gene targets. Only PPI interaction for homo sapiens were considered and a confidence score >0.4 was requested. The predicted 138 gene targets were mapped to 1,042 DEGs identified among three independent CF patient-related whole genome gene expression data sets. This identified seven genes in common and a total of 19 PPI.

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Genome Medicine

ISSN: 1756-994X

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