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Table 3 Knockout mouse phenotypes observed for the predicted, speculative biomarker candidates

From: Linking hypothetical knowledge patterns to disease molecular signatures for biomarker discovery in Alzheimer’s disease

S No,

Name of the candidate

Mutation category

Observed effect on the nervous system

1

LRP8

Targeted (knockouts)

Abnormal neuronal migration, abnormal brain development abnormal rostral migratory stream morphology, abnormal hippocampus development

2

CTSB

Targeted (knockouts)

Abnormal neuron apoptosis, abnormal hippocampus pyramidal cell layer gliosis neuron degeneration, Purkinje cell degeneration

3

GRM1

Targeted (knockouts)

Reduced long-term potentiation, reduced long-term depression

4

LDLR

Targeted (knockouts)

Abnormal CNS glial cell morphology, abnormal microglial cell morphology, abnormal astrocyte morphology, amyloid beta deposits, abnormal synaptic bouton