S No, | Name of the candidate | Mutation category | Observed effect on the nervous system |
---|---|---|---|
1 | LRP8 | Targeted (knockouts) | Abnormal neuronal migration, abnormal brain development abnormal rostral migratory stream morphology, abnormal hippocampus development |
2 | CTSB | Targeted (knockouts) | Abnormal neuron apoptosis, abnormal hippocampus pyramidal cell layer gliosis neuron degeneration, Purkinje cell degeneration |
3 | GRM1 | Targeted (knockouts) | Reduced long-term potentiation, reduced long-term depression |
4 | LDLR | Targeted (knockouts) | Abnormal CNS glial cell morphology, abnormal microglial cell morphology, abnormal astrocyte morphology, amyloid beta deposits, abnormal synaptic bouton |