|
Ebola
|
Acute
|
Close
|
Unknown; high case fatality in epidemics
|
No
|
No
|
None right now
|
Restricting civil liberties by using genomic information to inform quarantine policy or travel restrictions
|
|
Fairness implications of genotype-based triage decisions in resource-limited settings
|
|
Pandemic influenza
|
Acute
|
Casual
|
Variable
|
Yes, but variable
|
Yes, but variable
|
Markers associated with increased susceptibility to infection, severity of disease and response to vaccine
|
Imposing workforce restrictions on healthcare personnel or selectively excluding students who are more likely to be super-spreaders from educational settings during a pandemic
|
|
Hepatitis B
|
Chronic form
|
Close
|
Often Severe
|
Yes, but no cure
|
Yes (vaccine is 95% effective)
|
Markers associated with vaccine non-response
|
Prioritizing access to therapy for vaccine non-responders based on genotype, particularly in resource-limited settings
|
|
Exempting vaccine non-responders from job-dependent mandatory vaccination
|
|
Tuberculosis
|
Chronic, active form
|
Casual
|
Variable
|
Yes, but low efficacy, side effects and multidrug resistance
|
Vaccine only 20% effective
|
Markers associated with susceptibility to active disease in particular ethnic or geographic populations
|
Targeting specific, marginalized subgroups for genotyping (for example, prisoners, native populations, inner city communities) and then treating individuals differentially based on their genetic susceptibility to active infection
|
