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Figure 3 | Genome Medicine

Figure 3

From: Complex host genetics influence the microbiome in inflammatory bowel disease

Figure 3

Host genes with reproducible microbiome associations across cohorts. Network analysis of host signaling and metabolic pathways enriched for association with microbial taxa (FDR <0.25, Matthew’s correlation test). The visualization of gene-gene interaction network for the subset of 49 genes with significantly conserved directionalities of association with the microbiome is supported by several types of gene-gene connection [30]. This enrichment analysis identified enriched functional networks in innate immune response, inflammatory response, and the JAK-STAT pathway, all of which play roles in immune response to pathogen infection [1].

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