Figure 3From: Complex host genetics influence the microbiome in inflammatory bowel diseaseHost genes with reproducible microbiome associations across cohorts. Network analysis of host signaling and metabolic pathways enriched for association with microbial taxa (FDR <0.25, Matthew’s correlation test). The visualization of gene-gene interaction network for the subset of 49 genes with significantly conserved directionalities of association with the microbiome is supported by several types of gene-gene connection [30]. This enrichment analysis identified enriched functional networks in innate immune response, inflammatory response, and the JAK-STAT pathway, all of which play roles in immune response to pathogen infection [1].Back to article page