An integrated transcriptome and expressed variant analysis of sepsis survival and death

Table 2 Expressed sequence variants identified in VPS9D1

Chromosome (Start:Stop)	Variant type	Reference allele	Variant allele	cDNA change	Protein change	Variant impact	Reference SNP ID	Sepsis non-survivors	Sepsis survivors
16 (89774899:89774899)	Substitution	G	T	c.1738C > A	p.Leu580Met	Non-synonymous	rs182342705	0/20	0/69
16 (89775352:89775352)	Substitution	C	T	c.1610G > A	p.Arg537Gln	Non-synonymous		0/6	1/27
16 (89775776:89775776)	Substitution	T	G	c.1456A > C	p.Thr486Pro	Non-synonymous		2/26	30/74
16 (89777078:89777078)	Substitution	G	A	c.1174C > T	p.Arg392Trp	Non-synonymous	rs56288641	0/20	2/67
16 (89777123:89777123)	Substitution	C	T	c.1129G > A	p.Asp377Asn	Non-synonymous	rs148694296	0/23	1/68
16 (89777306:89777306)	Substitution	G	T	c.946C > A	p.Pro316Thr	Non-synonymous		0/25	2/76
16 (89777337:89777337)	Substitution	T	A	c.915A > T	p.Arg305Ser	Non-synonymous		0/15	2/67
16 (89777338:89777338)	Substitution	C	G	c.914G > C	p.Arg305Thr	Non-synonymous		0/16	2/66
16 (89777386:89777386)	Substitution	C	G	c.866G > C	p.Arg289Thr	Non-synonymous		0/23	2/74
16 (89777387:89777387)	Substitution	T	C	c.865A > G	p.Arg289Gly	Non-synonymous		0/23	2/74

A given subject may harbor more than one variant. Multiple transcripts and corresponding proteins exist for VPS9D1. cDNA and protein changes are based on VPS9D1 transcript NM_004913.2 and protein NP_004904.2.

ISSN: 1756-994X