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Figure 3 | Genome Medicine

Figure 3

From: Next generation sequencing analysis of nine Corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island

Figure 3

Phage infection of C. ulcerans can rapidly change its pathogenicity. (A) Genome Browser view of the annotated prophage region of KL387 and the corresponding region in KL392. The tRNA-Thr locus, which most likely serves as an integration site, is shown in red in the upper panel. The upper lane in both panels reflects the local GC content. In the region of the prophage the GC content is below the average GC content of C. ulcerans, as indicated by the purple color. Predicted genes are depicted as arrows below the GC content. Among other known prophage proteins we identified a phage integrase and a potential virulence factor sharing high identity with RhuM (45%) in the prophage of KL387. The dashed box indicates the putative prophage locus. (B) The additional prophage of KL387 contains a putative virulence factor similar to RhuM of Salmonella enterica. Multiple alignments of the putative virulence factor from KL387 (first row) with the RhuM virulence factor from Bacteroides fragilis (EXY75214.1), Vibrio parahaemolyticus (EVT77386.1), S. enterica (ESE75243.1), and Escherichia coli (EZJ48339.1) and the Fic toxin from Bacillus massiliosenegalensis (WP_019154237.1) and Lysinibacillus boronitolerans (WP_016992295.1). The amino acid sequences have been colored according to their similarity score according to the blosom 62 matrix: dark blue reflects identity, light blue a positive score and white no identity. CDS, coding sequence.

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