Figure 2
From: Clinical detection and characterization of bacterial pathogens in the genomics era
Principles of genome-based genotyping methods. By genomic comparison, investigators can identify specific sequence signatures that can be used in non-sequence-based methods (DNA banding-pattern-, PCR- or hybridization-based methods) or sequence-based methods (partial or complete genome sequencing). MLST, multi-locus sequence typing; MLVA, multiple locus variable number tandem repeat analysis; MST, muti-spacer sequence typing; PCR-RFLP, PCR-restriction fragment length polymorphism; PFGE, pulsed-field gel electrophoresis; RFLP, restriction fragment length polymorphism; SNP, single nucleotide polymorphism.