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Figure 4 | Genome Medicine

Figure 4

From: Transcriptome-wide signatures of tumor stage in kidney renal clear cell carcinoma: connecting copy number variation, methylation and transcription factor activity

Figure 4

The integrative model predicts expression alterations and TF activity changes. (A,B) The distribution of Spearman correlations of observed and predicted gene expression for all genes (A) and differentially expressed genes (B). The TF-only model (orange) is significantly better than random (blue, P < 2.2e-16), while the integrative model combining TFs, CNV and methylation (red) is significantly better than the TF only model (P < 2.2e-16). (C) Spearman correlations of observed and predicted expression changes for differentially expressed genes using random, TF-only, and the integrative model connecting TFs, CNV and methylation. (D) Candidate regulators associated with KIRC stage with effect size >0.5 and FDR <0.001.

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Genome Medicine

ISSN: 1756-994X

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