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Figure 4 | Genome Medicine

Figure 4

From: Bayesian models for syndrome- and gene-specific probabilities of novel variant pathogenicity

Figure 4

Pathogenicity prediction models for Brugada syndrome. The receiver operating characteristic curve for the full model for BrS is shown alongside that for LQTS (as in Figure 3) for comparison. Sensitivity could be improved at low false positive rates by building a combined model, in which some parameters were fit jointly for the LQTS and BrS models (see text for details) to compensate for the smaller BrS training set. Joint fitting does not impede performance of the LQTS model. BrS, Brugada syndrome; LQTS, long QT syndrome.

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