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Figure 5 | Genome Medicine

Figure 5

From: Bayesian models for syndrome- and gene-specific probabilities of novel variant pathogenicity

Figure 5

Comparison of pathogenicity prediction models for hypertrophic cardiomyopathy. Receiver operating characteristic curves for the full HCM model (full model, HCM) and a simpler gene model without domain-specific prediction (gene model, HCM) are shown alongside the LQTS classifier for comparison. As for BrS, the full HCM model was re-estimated in combination with the LQTS model with modest benefits at low false positive rates. BrS, Brugada syndrome; HCM, hypertrophic cardiomyopathy; LQTS, long QT syndrome.

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