Higher gene expression variability in the more aggressive subtype of chronic lymphocytic leukemia

Table 1 Functional enrichment of network modules

	Genes	Top enriched terms	Highly connected genes
Module 1	135	Cell death, cell differentiation and development	BCL2L1, PRKCA
Module 2	261	Ribosome, translation	LMO2, NR3C1, POU2F1, RARA, RBPJ, RPL14, YY1
Module 3	160	Signal transduction, cell communication, membrane, protein kinase activity, phosphorylation	ARHGEF6, BCL3, CAV1, CRK, FGFR1
Module 4	151	Transcription factor activity, DNA binding, gene expression	CCL2, JUND, STAT1
Module 5	179	Cell cycle	ATF2, CCNB2, CDC20, CDC25A, CREB1, E2F4, ESR1, FOXM1, MIKI67, MYC, POU2F2, RBL2, SP3, TYMS, UBE2C, VRK1

The first column shows the number of genes contained in every module of the network. The second column shows the top terms for which the corresponding module is enriched. The last column lists highly connected genes (degree ≥35) of the corresponding module ordered alphabetically.

ISSN: 1756-994X