Skip to main content
Figure 5 | Genome Medicine

Figure 5

From: Ploidy-Seq: inferring mutational chronology by sequencing polyploid tumor subpopulations

Figure 5

Chronology of somatic mutations and interaction networks. (a-c) Non-synonymous point mutations detected in the breast tumor subpopulations (a) Distribution of allele frequencies of the non-synonymous mutations. (b) Heatmap of the non-synonymous mutations ordered by relative chronology. Point mutations in cancer genes are highlighted in red. (c) Percentage of somatic mutations detected in the TCGA breast tumor patient cohort. (d) Network analysis of the point mutations that were temporally deregulated during tumor evolution. (e) Detection efficiency of simulated bulk data at different coverage depths.

Back to article page