Figure 1From: Rare variant association studies: considerations, challenges and opportunities Comparison of power for trios and case–control designs. Power to detect associations for 10,000 cases and 10,000 controls (blue) and 10,000 trios (red) across a range of minor allele frequencies (MAFs). Power was calculated with a significance threshold of P < 0.05, a prevalence of 0.1 and a relative risk of 1.1, using the Genetic Power Calculator tool [112].Back to article page