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Figure 2 | Genome Medicine

Figure 2

From: Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines

Figure 2

Transcriptomic signature characterizing cell lines resistant to thiopurines. (A) Heatmap of the transcriptomic signature validated by qPCR for resistant (orange) compared to sensitive (blue) cell lines. Overexpressed genes are in red and underexpressed genes in green. Fold-changes in the relative expression of each gene are reported in Additional file 1: Table S5. (B) Validation by qPCR of the transcriptomic signature including 32 genes. Fold-changes in the relative expression of each of the 32 genes as determined using qPCR (X axis) and micro-array (Y axis), with GUSB as the reference gene (r s  = 0.87; P <0.0001).

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