Table 1 Characteristics of lymphoblastoid cell lines
From: Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines
|  | Resistant (n = 5) | Sensitive (n = 6) | P |
|---|---|---|---|
Growth inhibition by 6-MP (%) | 11.8 ± 2.1 | 39.8 ± 2.3 | 0.008 |
Basal growth rate per day | 0.3 ± 0.06 | 0.5 ± 0.04 | 0.052 |
EBV copy number (absolute) | 110 ± 35 | 47 ± 11 | 0.17 |
mtDNA copy number (relative) | 1.5 ± 0.2 | 2.4 ± 0.3 | 0.08 |
Intracellular ATP level (μmol/106 cells) | 23.9 ± 2.6 | 19.0 ± 1.8 | 0.25 |
TPMT activity (pmol/h/mg protein) | 425 ± 20 | 295 ± 24 | 0.024 |
HPRT activity (nmol/h/mg protein) | 621 ± 12 | 576 ± 57 | 1.0 |