Table 3 Upstream regulator analysis of the resistant compared to the sensitive cell lines
From: Molecular insight into thiopurine resistance: transcriptomic signature in lymphoblastoid cell lines
Symbol | Description | Regulator type | Predicted activation state | P value of overlap (<0.01) | Target genes differentially expressed in micro-array |
|---|---|---|---|---|---|
FOXM1 | Forkhead box M1 | Transcription regulator | Inhibited | 4.71E-07 | ATF2, BIRC5, BUB1B, CCNA2, CCNB1, CDC25A, CDKN3, CENPA, CENPB, FOXM1, GTSE1, MMP2, PLK1 |
TP53 | Tumor protein p53 | Transcription regulator | Activated | 6.41E-05 | ACLY, ACTA2, APAF1, ATG10, BIRC5, BTG1, BUB1B, CCNA2, CCNB1, CCNG2, CDC25A, CDC25C, CDKN3, CHUK, CLPP, CYB5A, DDB2, E2F1, EDA2R, EIF4G3, FASN, FBXW7, GNL3, GTSE1, HBEGF, HIF1A, HK2, IPO7, JMJD1C, KIF23, KPNA2, MET, MMP2, NDC80, NPEPPS, NUP153, OAT, ORAI2, PDK1, PIDD, PLK1, PSMD12, PSME3, PVT1, RAD50, RAD54B, RBL2, RFC3, RPS6KB1, SCO2, SFPQ, SGPL1, SLC19A1, SPC25, SQLE, STARD4, TIMM44, TLR6, TMEM97, TRIM28, UBE2C, USO1, USP14, ZFP36L1 |
FLI1 | Fli-1 proto-oncogene, ETS transcription factor | Transcription regulator | Inhibited | 6.18E-04 | DDX21, NIP7, NOL6, NOLC1, SNRPB, TCP1 |
MYC | v-myc avian myelocytomatosis viral oncogene homolog | Transcription regulator | Inhibited | 7.33E-04 | ASNS, BIRC2, BUB1B, CCNA2, CCNB1, CCNG2, CDC25A, CNBP, DCTPP1, DDB2, DKC1, E2F1, FASN, FOXM1, FTH1, GOT1, GTF2B, HIF1A, HK2, IPO7, ITGA6, MAT2A, NOLC1, OAT, PDK1, PHF21A, PLK1, SHMT2, SLC1A5, SLC3A2, SLC7A5, SNRPD1, SPRR2G, TIMM23, TMEM126A, TXNRD1, UBE2C |
CD24 | CD24 molecule | Other | Activated | 8.97E-04 | CHAC1, DNAJC13, JMJD1C, MBNL1, RAD50, SCAF11, SFPQ, SPG11, USO1, VPS13B, VPS13C |
NUPR1 | Nuclear protein, transcriptional regulator, 1 | Transcription regulator | Activated | 2.14E-03 | BTG1, BUB1B, CCNA2, CDC25C, CDCA2, CDCA8, CHUK, EGLN1, FUT11, GINS1, GPCPD1, GTSE1, HBEGF, HILPDA, HIST1H2AB/HIST1H2AE, HIST1H3A, HK2, KDM3A, KIF23, MAT2A, MTFMT, MTFR2, PDK1, PLK1, RAB7L1, RIMKLA, RNU11, SPC25, UBIAD1, ZFP36L1, ZNF259 |
CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | Kinase | Activated | 2.36E-03 | ACTA2, BIRC5, CCNA2, CCNB1, CDC25A, CDC25C, FOXM1, PLK1, RBL2 |
CSF2 | Colony stimulating factor 2 (granulocyte-macrophage) | Cytokine | Inhibited | 4.34E-03 | BIRC5, BUB1B, CCNA2, CDC123, CDCA2, CDCA8, CEACAM1, FOXM1, ITGAX, MAT2A, PLK1, PPIF, SKA1, SLC1A5, SPC25, TRIP13, UBE2C |
CCND1 | Cyclin D1 | Other | Inhibited | 5.45E-03 | BIRC5, BRWD1, CCNA2, CDCA2, CDCA8, CENPN, E2F1, FOXM1, MTFR2, PLK1, SPC25, STARD4, TBCK, TOR3A, TRIP13 |