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Table 1 Eligibility criteria for BRIDGE bleeding and platelet disorders study

From: Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders

Inclusion criteria

Exclusion criteria

Platelet count less than 100 × 109/L or greater than 400 × 109/L, or

Acquired bleeding or platelet disorders, including any of the following:

Mean platelet volume less than 6 fL or greater than 12 fL, or

Use of any medication known to affect platelet function or cause bleeding

Reproducible abnormal platelet function test results, or

Immune thrombocytopenia

Abnormal platelet morphology by light or electron microscopy, or

HIV infection

Pathological bleeding of unknown aetiology, and

Malignancies, particularly those affecting haemopoiesis

Considered by referring clinician to be of genetic aetiology

Bone marrow aplasia

 

Thrombotic thrombocytopenic purpura/ Haemolytic-uremic syndrome

 

Acute viral infection

 

Splenomegaly

 

Uraemia or hepatic failure