Inclusion criteria | Exclusion criteria |
---|---|
Platelet count less than 100 × 109/L or greater than 400 × 109/L, or | Acquired bleeding or platelet disorders, including any of the following: |
Mean platelet volume less than 6 fL or greater than 12 fL, or | Use of any medication known to affect platelet function or cause bleeding |
Reproducible abnormal platelet function test results, or | Immune thrombocytopenia |
Abnormal platelet morphology by light or electron microscopy, or | HIV infection |
Pathological bleeding of unknown aetiology, and | Malignancies, particularly those affecting haemopoiesis |
Considered by referring clinician to be of genetic aetiology | Bone marrow aplasia |
 | Thrombotic thrombocytopenic purpura/ Haemolytic-uremic syndrome |
 | Acute viral infection |
 | Splenomegaly |
 | Uraemia or hepatic failure |