GO enrichment analysis comparing baseline in active sites to progression profiles in the same sites. Enriched terms obtained using GOseq were summarized and visualized as a scatter plot using REVIGO. (A) Summarized GO terms related to biological processes at baseline. (B) Summarized GO terms related to biological processes in progression. Circle size is proportional to the frequency of the GO term, while color indicates the log10 P value (red higher, blue lower).