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Figure 3 | Genome Medicine

Figure 3

From: ClinSeK: a targeted variant characterization framework for clinical sequencing

Figure 3

ClinSeK performance in analyzing DNA-seq and RNA-seq data. (A) Comparison of ClinSeK, VarScan2 and MuTect sensitivity in characterizing somatic mutations from 1,024 targeted exome-sequenced tumor and normal pairs. Text box lists CLIA-validated somatic mutations detected only by ClinSeK. (B) Comparison of ClinSeK and the base-to-base pipeline in runtime (blue dots) and data storage (green dots). Dashed lines correspond to 80× and 200× respective reductions in runtime and storage. Dot sizes are proportional to the number of reads sequenced from each sample. (C) Illustration of ClinSeK gene fusion detection results on The Cancer Genome Atlas (TCGA) samples. Black horizontal bars indicate breakpoints. Text boxes list TCGA sample names, in which the corresponding fusion is detected.

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