Skip to main content

Advertisement

Table 1 Tumors with high proportions of A:T > T:A mutations

From: Mutation signatures implicate aristolochic acid in bladder cancer development

   Mutations attributed to AA Mutation count A:T > T:A proportion A > T Count Non-transcribed
/(all A > T)
Strand bias A:T > T:A cosine similarity with AA signature
Sample Cancer type Proportion Total A:T > T:A P FDR Non-transcribed Transcribed   P FDR
9T UTUC 0.97 2386 2008 0 0 1505 503 0.75 8E-116 3E-113 0.987
20T UTUC 0.96 1933 1641 0 0 1265 376 0.77 1E-112 2E-110 0.995
K100T UTUC 0.97 2342 1982 0 0 1435 547 0.72 9E-92 1E-89 0.992
6T UTUC 0.95 1552 1302 0 0 994 308 0.76 1E-84 9E-83 0.995
K80T UTUC 0.98 1713 1480 0 0 1100 380 0.74 1E-81 1E-79 0.988
13T UTUC 0.99 1409 1222 0 0 924 298 0.76 3E-75 2E-73 0.994
K79T UTUC 0.99 1573 1374 0 0 1015 359 0.74 5E-73 3E-71 0.992
130T Bladder 0.82 1366 980 0 0 708 272 0.72 1E-45 5E-44 0.992
HK41T HCC 0.95 781 630 0 0 441 189 0.70 2E-24 7E-23 0.988
3T UTUC 0.91 666 524 0 0 369 155 0.70 2E-21 6E-20 0.959
136T Bladder 0.73 688 450 1E-229 4E-228 339 111 0.75 3E-28 1E-26 0.987
10T UTUC 0.73 545 351 3E-176 9E-175 263 88 0.75 1E-21 4E-20 0.972
HK2B_8d2 AA-treated cell line 0.73 413 264 7E-132 2E-130 178 86 0.67 8E-09 2E-07 0.972
GZ75T HCC 0.71 404 250 4E-120 1E-118 167 83 0.67 6E-08 2E-06 0.975
HK2_AA AA-treated cell line 0.66 261 152 2E-68 4E-67 107 45 0.70 3E-07 6E-06 0.905
33324197T Bladder 0.42 182 67 5E-17 1E-15 46 21 0.69 2E-03 3E-02 0.942
B23 Bladder 0.36 241 76 9E-15 2E-13 56 20 0.74 2E-05 4E-04 0.949
HK174T HCC 0.48 109 46 1E-14 2E-13 24 22 0.52 0.44 0.85 0.886
HK65T HCC 0.47 119 48 2E-14 5E-13 41 7 0.85 3E-07 7E-06 0.889
B77 Bladder 0.45 106 42 2E-12 4E-11 38 4 0.90 3E-08 8E-07 0.927
HK81T HCC 0.45 101 39 3E-11 5E-10 26 13 0.67 3E-02 0.26 0.893
GZ119T HCC 0.46 59 25 1E-08 2E-07 17 8 0.68 5E-02 0.40 0.736
B89-12 Bladder 0.3 238 62 1E-08 2E-07 48 14 0.77 9E-06 2E-04 0.950
HK267T HCC 0.43 61 23 5E-07 8E-06 18 5 0.78 5E-03 7E-02 0.833
HK75T HCC 0.41 67 24 9E-07 1E-05 12 12 0.50 0.58 1 0.871
21T UTUC 0.34 76 24 1E-05 2E-04 17 7 0.71 3E-02 0.27 0.860
TCGA-K4-A6FZ-01A-11D-A31L-08 Bladder 0.18 461 83 4E-04 6E-03 52 31 0.63 1E-02 0.15 0.525
1T UTUC 0.27 70 18 2E-03 3E-02 17 1 0.94 7E-05 1E-03 0.777
  1. HCC, hepatocellular carcinoma; NA, not applicable; UTUC, upper urinary tract urothelial cell carcinoma.