From: Mutation signatures implicate aristolochic acid in bladder cancer development
 |  | Mutations attributed to AA | Mutation count | A:T > T:A proportion | A > T Count | Non-transcribed /(all A > T) | Strand bias | A:T > T:A cosine similarity with AA signature | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Sample | Cancer type | Proportion | Total | A:T > T:A | P | FDR | Non-transcribed | Transcribed | Â | P | FDR | |
9T | UTUC | 0.97 | 2386 | 2008 | 0 | 0 | 1505 | 503 | 0.75 | 8E-116 | 3E-113 | 0.987 |
20T | UTUC | 0.96 | 1933 | 1641 | 0 | 0 | 1265 | 376 | 0.77 | 1E-112 | 2E-110 | 0.995 |
K100T | UTUC | 0.97 | 2342 | 1982 | 0 | 0 | 1435 | 547 | 0.72 | 9E-92 | 1E-89 | 0.992 |
6T | UTUC | 0.95 | 1552 | 1302 | 0 | 0 | 994 | 308 | 0.76 | 1E-84 | 9E-83 | 0.995 |
K80T | UTUC | 0.98 | 1713 | 1480 | 0 | 0 | 1100 | 380 | 0.74 | 1E-81 | 1E-79 | 0.988 |
13T | UTUC | 0.99 | 1409 | 1222 | 0 | 0 | 924 | 298 | 0.76 | 3E-75 | 2E-73 | 0.994 |
K79T | UTUC | 0.99 | 1573 | 1374 | 0 | 0 | 1015 | 359 | 0.74 | 5E-73 | 3E-71 | 0.992 |
130T | Bladder | 0.82 | 1366 | 980 | 0 | 0 | 708 | 272 | 0.72 | 1E-45 | 5E-44 | 0.992 |
HK41T | HCC | 0.95 | 781 | 630 | 0 | 0 | 441 | 189 | 0.70 | 2E-24 | 7E-23 | 0.988 |
3T | UTUC | 0.91 | 666 | 524 | 0 | 0 | 369 | 155 | 0.70 | 2E-21 | 6E-20 | 0.959 |
136T | Bladder | 0.73 | 688 | 450 | 1E-229 | 4E-228 | 339 | 111 | 0.75 | 3E-28 | 1E-26 | 0.987 |
10T | UTUC | 0.73 | 545 | 351 | 3E-176 | 9E-175 | 263 | 88 | 0.75 | 1E-21 | 4E-20 | 0.972 |
HK2B_8d2 | AA-treated cell line | 0.73 | 413 | 264 | 7E-132 | 2E-130 | 178 | 86 | 0.67 | 8E-09 | 2E-07 | 0.972 |
GZ75T | HCC | 0.71 | 404 | 250 | 4E-120 | 1E-118 | 167 | 83 | 0.67 | 6E-08 | 2E-06 | 0.975 |
HK2_AA | AA-treated cell line | 0.66 | 261 | 152 | 2E-68 | 4E-67 | 107 | 45 | 0.70 | 3E-07 | 6E-06 | 0.905 |
33324197T | Bladder | 0.42 | 182 | 67 | 5E-17 | 1E-15 | 46 | 21 | 0.69 | 2E-03 | 3E-02 | 0.942 |
B23 | Bladder | 0.36 | 241 | 76 | 9E-15 | 2E-13 | 56 | 20 | 0.74 | 2E-05 | 4E-04 | 0.949 |
HK174T | HCC | 0.48 | 109 | 46 | 1E-14 | 2E-13 | 24 | 22 | 0.52 | 0.44 | 0.85 | 0.886 |
HK65T | HCC | 0.47 | 119 | 48 | 2E-14 | 5E-13 | 41 | 7 | 0.85 | 3E-07 | 7E-06 | 0.889 |
B77 | Bladder | 0.45 | 106 | 42 | 2E-12 | 4E-11 | 38 | 4 | 0.90 | 3E-08 | 8E-07 | 0.927 |
HK81T | HCC | 0.45 | 101 | 39 | 3E-11 | 5E-10 | 26 | 13 | 0.67 | 3E-02 | 0.26 | 0.893 |
GZ119T | HCC | 0.46 | 59 | 25 | 1E-08 | 2E-07 | 17 | 8 | 0.68 | 5E-02 | 0.40 | 0.736 |
B89-12 | Bladder | 0.3 | 238 | 62 | 1E-08 | 2E-07 | 48 | 14 | 0.77 | 9E-06 | 2E-04 | 0.950 |
HK267T | HCC | 0.43 | 61 | 23 | 5E-07 | 8E-06 | 18 | 5 | 0.78 | 5E-03 | 7E-02 | 0.833 |
HK75T | HCC | 0.41 | 67 | 24 | 9E-07 | 1E-05 | 12 | 12 | 0.50 | 0.58 | 1 | 0.871 |
21T | UTUC | 0.34 | 76 | 24 | 1E-05 | 2E-04 | 17 | 7 | 0.71 | 3E-02 | 0.27 | 0.860 |
TCGA-K4-A6FZ-01A-11D-A31L-08 | Bladder | 0.18 | 461 | 83 | 4E-04 | 6E-03 | 52 | 31 | 0.63 | 1E-02 | 0.15 | 0.525 |
1T | UTUC | 0.27 | 70 | 18 | 2E-03 | 3E-02 | 17 | 1 | 0.94 | 7E-05 | 1E-03 | 0.777 |