Table 1 Summary of mutations included in the curated whole genome drug resistance library
From: Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
Drug | Loci | No. variable sites | SNPs | Indels |
|---|---|---|---|---|
INH | katG | 241 | 286 | 25 |
katG promoter | 3 | 3 | 0 | |
inhA | 12 | 15 | 0 | |
inhA promoter | 9 | 11 | 0 | |
ahpC | 8 | 8 | 0 | |
ahpC promoter | 13 | 14 | 0 | |
kasA | 8 | 11 | 0 | |
RMP | rpoB | 89 | 135 | 19 |
rpoC | 8 | 8 | 0 | |
EMB | embB | 123 | 153 | 1 |
embA | 5 | 5 | 0 | |
embA promoter | 3 | 3 | 0 | |
embC | 25 | 26 | 0 | |
embR | 22 | 24 | 0 | |
STR | rrs | 21 | 25 | 0 |
rpsL | 14 | 19 | 0 | |
PZA | pncA | 215 | 269 | 64 |
pncA promoter | 4 | 6 | 0 | |
rpsA | 3 | 4 | 0 | |
panD | 9 | 11 | 1 | |
ETH | ethA | 33 | 29 | 5 |
ethR | 3 | 4 | 0 | |
inhA promoter | 3 | 3 | 0 | |
inhA | 3 | 3 | 0 | |
FLQs | gyrA | 15 | 22 | 0 |
gyrB | 22 | 29 | 0 | |
AMK | rrs | 8 | 9 | 0 |
CAP | rrs | 3 | 4 | 0 |
tlyA | 26 | 18 | 10 | |
KAN | rrs | 3 | 4 | 0 |
eis promoter | 9 | 10 | 0 | |
PAS | thyA | 23 | 17 | 5 |
folC | 16 | 19 | 0 | |
ribB | 1 | 1 | 0 | |
LZD | rrl | 2 | 2 | 0 |
rplC | 1 | 1 | 0 | |
BDQ CFZ | Rv0678 | 7 | 5 | 2 |