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Table 1 Summary of mutations included in the curated whole genome drug resistance library

From: Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

Drug Loci No. variable sites SNPs Indels
INH katG 241 286 25
  katG promoter 3 3 0
  inhA 12 15 0
  inhA promoter 9 11 0
  ahpC 8 8 0
  ahpC promoter 13 14 0
  kasA 8 11 0
RMP rpoB 89 135 19
  rpoC 8 8 0
EMB embB 123 153 1
  embA 5 5 0
  embA promoter 3 3 0
  embC 25 26 0
  embR 22 24 0
STR rrs 21 25 0
  rpsL 14 19 0
PZA pncA 215 269 64
  pncA promoter 4 6 0
  rpsA 3 4 0
  panD 9 11 1
ETH ethA 33 29 5
  ethR 3 4 0
  inhA promoter 3 3 0
  inhA 3 3 0
FLQs gyrA 15 22 0
  gyrB 22 29 0
AMK rrs 8 9 0
CAP rrs 3 4 0
  tlyA 26 18 10
KAN rrs 3 4 0
  eis promoter 9 10 0
PAS thyA 23 17 5
  folC 16 19 0
  ribB 1 1 0
LZD rrl 2 2 0
  rplC 1 1 0
BDQ CFZ Rv0678 7 5 2
  1. AMK, amikacin; BDQ, bedaquiline; CAP, capreomycin; CFZ, clofazimine; EMB, ethabutol; ETH, ethionamide; FLQs, fluoroquinolones; INH, isoniazid; KAN, kanamycin; LZD, linezolid; PAS, para-aminosalycylic acid; PZ, pyrazinamide; RMP, rifampicin; STR, streptomycin.