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Fig. 5 | Genome Medicine

Fig. 5

From: Widespread intron retention diversifies most cancer transcriptomes

Fig. 5

Retained introns are frequently found in the cytoplasm. Intron retention in the nuclear versus cytoplasmic subcellular fractions of MCF-7 (a) and K562 (b) cell lines, categorized by how frequently the introns are differentially spliced in primary breast cancer or AML samples. Left, introns that are differentially spliced in <25 % of samples from the corresponding primary cancer; center, introns that are retained in more cancer samples than normal controls; right, introns that are retained in more normal controls than cancer samples. The left, center, and right panels are mutually exclusive. Each dot represents a single intron. The dot size is proportional to the number of patients the intron is differentially spliced in, and the dot color intensity represents the proportion of patients where it is retained in the tumor (red) versus the control (blue). Introns lying above the dashed line are retained in >10 % of cytosolic transcripts

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