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Table 1 Summary of differential splicing across cancer types

From: Widespread intron retention diversifies most cancer transcriptomes

 

Patients (n)

Coverage (106 reads)

Cassette exons

Competing 5′ splice sites

Competing 3′ splice sites

Retained introns

Constitutive introns

Constitutive junctions

Retained intron ratio

Acute myeloid leukemia

169

75 (8)

1,219

326

377

973

6,239

841

4.74 (1.2)

Bladder

18

56 (14)

894

170

211

296

552

456

1.83 (2.2)

Breast

104

72 (17)

1,052

210

268

266

612

569

-2.01 (2.1)

Colon

37

58 (18)

597

165

200

307

376

291

3.44 (2.6)

Endometrium

21

35 (16)

619

171

180

296

370

312

0.48 (2.4)

Head and neck

40

81 (26)

829

153

202

115

290

418

0.82 (1.7)

Kidney (chromophobe)

25

82 (12)

941

184

228

207

481

484

1.65 (1.4)

Kidney (renal clear cell)

71

80 (16)

729

149

194

143

380

380

1.42 (1.7)

Kidney (renal papillary cell)

30

85 (20)

730

155

220

184

440

408

1.51 (2.1)

Liver

50

70 (15)

413

90

117

106

200

206

0.82 (2.1)

Lung (adenocarcinoma)

51

43 (28)

517

115

141

176

277

233

0.20 (2.6)

Lung (squamous cell)

50

83 (31)

1,068

190

252

236

609

547

0.44 (2.0)

Prostate

43

75 (11)

607

133

185

130

358

337

1.44 (2.4)

Stomach

30

105 (21)

1,048

200

302

206

886

884

0.99 (1.7)

Rectum

8

53 (14)

680

123

172

310

390

314

4.30 (2.3)

Thyroid

58

83 (11)

533

132

177

174

488

332

0.66 (2.4)

  1. Read coverage, number of differentially spliced isoforms, and bias between intron retention in tumor samples compared to patient-matched normal controls Numbers are medians (standard deviation) across all samples