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Fig. 4 | Genome Medicine

Fig. 4

From: A bioinformatic framework for immune repertoire diversity profiling enables detection of immunological status

Fig. 4

Diversity and Evenness profiles resolve stages of hematopoietic stem cell transplantation. a–d Hierarchical clustering was performed based on Euclidean distance for Diversity profiles and correlation-based distance for Evenness profiles of dataset 1 and visualized using heatmaps. The heatmaps depict the pairwise distances/Pearson correlation coefficients of all profiles determined (see Methods for further details). Both for CD4 and CD8 T-cell repertoires, Diversity (a, c) and Evenness (b, d) profiles from 'Month 2' (blue) after transplantation cluster together as do profiles of 'Baseline' measurements (green) and 'Month 12' (red) after transplantation (red color bar). Of note, for CD8 datasets, Diversity profiles cluster almost perfectly by each of the three statuses (Baseline, Month 2, Month 12). Diversity and Evenness profiles were calculated in a range of alpha = 0 to alpha = 10 with a step size of 0.2. Sample numbers: 24 per immunological status and T-cell population

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