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Table 1 Average frequencies of variants in 56 ACMG SF genes among five ethnic groups

From: Secondary findings and carrier test frequencies in a large multiethnic sample

Population

European Americans (ARIC)

Europeans (CMG)

African Americans (ARIC)

Africans (CMG)

Turks (CMG)

Hispanics (CMG)

Asians (CMG)

Number of samples

5718

1455

2836

122

498

388

51

Average number of nonsynonymous variants per individual

1.683

1.878

3.159

2.852

2.271

2.472

2.667

Fraction of individuals with nonsynonymous variants

0.807

0.84

0.955

0.959

0.896

0.93

0.922

Average number of predicted deleterious variants per individual

0.612

0.737

0.963

0.779

0.865

0.765

0.843

Fraction of individuals with predicted deleterious variants

0.449

0.529

0.615

0.549

0.578

0.539

0.569

Average number of ClinVar variants per individual

0.06

0.049

0.06

0.057

0.056

0.044

0.137

Fraction of individuals with ClinVar variants

0.058

0.048

0.058

0.057

0.052

0.044

0.137

Average number of HGMD variants per individual

0.416

0.463

0.485

0.459

0.4

0.428

0.412

Fraction of individuals with HGMD-DM variants

0.335

0.355

0.38

0.393

0.333

0.34

0.353

Average number of nonsense variants per individual

0.007

0.006

0.013

0.008

0.008

0.003

0

Fraction of individuals with nonsense variants

0.007

0.006

0.013

0.008

0.008

0.003

0

  1. These frequencies are reported for: 1) all rare nonsynonymous variants, 2) predicted deleterious variants, 3) reported pathogenic ClinVar variants, 4) HGMD-DM variants, 5) nonsense variants