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Table 1 Worldwide distribution of OCT1 alleles

From: Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

World region Population N chr. Major OCT1 alleles
*1 *2 *3 *4 *5 *6 *7 *8 *9 *10 *11 *12 *13 *14 *15 *16
Sub-Saharan Africa San 6 12 91.7 0 0 0 0 0 0 8.3 0 0 0 0 0 0 0 0
Mbuti Pygmy 13 26 76.9 7.7 0 0 0 0 0 15.4 0 0 0 0 0 0 0 0
Biaka Pygmy 26 52 76.9 11.5 0 0 0 0 9.6 1.9 0 0 0 0 0 0 0 0
Bantu S.W. 8 16 87.5 6.3 0 0 0 0 6.3 0 0 0 0 0 0 0 0 0
Bantu N.E. 11 22 63.6 9.1 0 0 0 0 9.1 18.2 0 0 0 0 0 0 0 0
Bantu (LWK-1 K) 97 194 88.1 4.1 0 0 0 0 2.6 5.1 0 0 0 0 0 0 0 0
Mandenka 22 44 90.9 4.6 0 0 0 0 2.3 2.3 0 0 0 0 0 0 0 0
Yoruba 22 44 95.5 0 0 0 0 0 2.3 2.3 0 0 0 0 0 0 0 0
Yoruba (YRI-1 K) 88 176 90.3 2.3 0 0 0 0 1.7 5.7 0 0 0 0 0 0 0 0
Sub-Saharan Africa mean 293 586 84.6 5.1 0 0 0 0 3.8 6.6   0 0 0 0 0 0 0
(range)    (63.6-95.5) (0.0-11.5)      (0.0-9.6) (0.0-18.2)         
North Africa and Middle East Mozabite 29 58 82.8 12.1 0 1.72 0 1.72 1.72 0 0 0 0 0 0 0 0 0
Bedouin 46 92 72.8 9.8 10.9 0 3.26 0 2.17 1.1 0 0 0 0 0 0 0 0
Palestinian 45 90 78.9 13.3 3.33 0 0 2.22 2.22 0 0 0 0 0 0 0 0 0
Druze 42 84 77.4 17.9 4.76 0 0 0 0 0 0 0 0 0 0 0 0 0
North Africa and Middle East mean 162 324 78.2 13.3 4.7 0.4 0.8 1.0 1.5 0.3 0 0 0 0 0 0 0 0
(range)    (73.9-82.8) (9.8-17.9) (0.0-10.9) (0.0-1.7) (0.0-3.3) (0.0-2.2) (0.0-2.2) (0.0-1.12)         
Europe Tuscan 8 16 87.5 12.5 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Tuscan (TSI-1 K) 98 196 71.9 18.9 5.6 2.55 0.51 0 0 0.5 0 0.5 0 0 0 0 0 0
Sardinian 28 56 69.6 21.4 1.8 5.36 0 1.79 0 0 0 0 0 0 0 0 0 0
North Italian 14 28 89.3 7.14 3.6 0 0 0 0 0 0 0 0 0 0 0 0 0
Iberian (IBS-1 K) 14 28 75.0 14.3 3.6 7.14 0 0 0 0 0 0 0 0 0 0 0 0
French Basque 24 48 72.9 18.8 4.2 4.17 0 0 0 0 0 0 0 0 0 0 0 0
French 28 56 62.5 21.4 7.14 1.79 5.36 1.79 0 0 0 0 0 0 0 0 0 0
British (GBR-1 K) 89 178 72.5 16.3 5.06 2.25 3.37 0.56 0 0 0 0 0 0 0 0 0 0
Orcadian 15 30 80.0 13.3 6.67 0 0 0 0 0 0 0 0 0 0 0 0 0
German 117 234 71.4 15.8 8.12 2.14 2.56 0 0 0 0 0 0 0 0 0 0 0
Finn (FIN-1 K) 93 186 78.5 13.4 5.38 1.61 1.08 0 0 0 0 0 0 0 0 0 0 0
Adygei 17 34 70.6 17.6 5.88 0 2.94 0 0 0 0 2.94 0 0 0 0 0 0
  Russian 25 50 66.0 10.0 10.0 6.00 8.00 0 0 0 0 0 0 0 0 0 0 0
Europe mean 570 1,140 74.4 15.5 5.1 2.5 1.8 0.3 0 0.04   0.3 0 0 0 0 0 0
(range)    (62.5-89.3) (7.1-21.4) (0.0-10.0) (0.0-7.1) (0.0-8.0) (0.0-1.8)   (0.0-0.5)   (0.0-2.94)       
Central Asia Balochi 24 48 66.7 27.1 6.25 0 0 0 0 4.2 0 0 0 0 0 0 0 0
Brahui 25 50 62.0 26.0 6.00 0 6 0 0 0 0 0 0 0 2 0 0 0
Makrani 25 50 84.0 16.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Sindhi 24 48 83.3 12.5 0 0 0 0 4.17 0 0 0 0 0 0 0 0 0
Pathan 25 50 72 26 2 0 0 0 0 0 0 0 0 0 0 0 0 0
Kalash 23 46 73.9 19.6 6.52 0 0 0 0 0 0 0 0 0 2.17 0 0 0
Burusho 25 50 84 6 6 0 4.00 0 0 0 0 0 0 0 0 0 0 0
Hazara 23 46 89.1 4.35 2.17 0 0 2.17 0 0 0 0 0 0 0 2.17 0 0
Uygur 10 20 80 15 5 0 0 0 0 0 0 0 0 0 0 0 0 0
  Yakut 25 50 92.0 0 4.00 0 0 0 0 0 4.00 0 0 0 0 0 0 0
Central Asia mean 229 458 78.7 14.8 3.8 0 1.0 0.2 0.4 0.42 0.4 0 0 0 0.4 0.2 0 0
(range)    (62.0-92.0) (0.0-27.1) (0.0-6.5)   (0.0-6.0) (0.0-2.2) (0.0-4.2) (0.0-4.2) (0.0-4.0)     (0.0-2.2) (0.0-2.2)   
East Asia and Oceania Dai 10 20 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
She 10 20 90.0 0 0 0 0 0 0 0 0 0 0 10.0 0 0 0 0
Tujia 10 20 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Yizu 10 20 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Naxi 9 18 94.4 0 0 0 0 0 0 0 0 0 5.56 0 0 0 0 0
Tu 10 20 90.0 0 0 0 0 0 0 0 0 0 0 0 0 0 5.0 0
Xibo 9 18 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mongola 10 20 85.0 10.0 0 0 0 0 0 0 5.00 0 0 0 0 0 0 0
Hezhen 9 18 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Daur 10 20 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Oroqen 9 18 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Han 45 90 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Han Beijing (CHB-1 K) 97 194 98.5 0.52 0 0 0 0 0 0 0.52 0 0.52 0 0 0 0 0
Han South(CHS-1 K) 100 200 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Lahu 8 16 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Miaozu 10 20 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cambodian 10 20 95.0 5.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Japanese 30 60 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Japanese (JPT-1 K) 89 178 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Melanesian 14 28 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
  Papuan 17 34 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
East Asia and Oceania mean 526 1,052 97.8 0.7 0 0 0 0 0 0 0.3 0 0.3 0.5 0 0 0.2 0.2
(range)     (85.0-100.0) (0.0-10.0)        (0.0-5.0)   (0.0-5.6) (0.0-10.0)    (0.0-5.0) (0.0-5.0)
America Colombian 7 14 57.1 42.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Karitiana 14 28 39.3 60.7 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Maya 21 42 66.7 33.3 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Pima 14 28 82.1 17.9 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Surui 8 16 6.25 93.8 0 0 0 0 0 0 0 0 0 0 0 0 0 0
America mean   64 128 50.3 49.7 0 0 0 0 0 0 0 0 0 0 0 0 0 0
(range)     (6.3-82.1) (17.9-93.7)               
Admixed populations Colombian (CLM-1 K) 60 120 65.8 29.2 3.33 0.83 0.83 0 0 0 0 0 0 0 0 0 0 0
Mexican (MXL-1 K) 66 132 59.1 32.6 4.55 0 3.03 0 0.76 0 0 0 0 0 0 0 0 0
Puerto Rican (PUR-1 K) 55 110 76.4 20.0 0.91 0 1.82 0 0 0 0 0.91 0 0 0 0 0 0
Caucasians (CEU-1 K) 85 170 72.4 15.3 8.82 1.76 1.18 0.59 0 0 0 0 0 0 0 0 0 0
Africans (ASW-1 K) 61 122 87.7 8.20 1.64 0.82 0 0 0.82 0 0 0 0 0 0 0 0 0.82
Worldwide mean   2,171 4,342 81.0 12.2 2.14 0.57 0.65 0.16 0.68 0.99 0.14 0.07 0.09 0.15 0.07 0.03 0.07 0.01
(range)     (6.3-100.0) (0.0-93.8) (0.0-10.9) (0.0-7.1) (0.0-8.0) (0.0-2.2) (0.0-9.6) (0.0-18.2) (0.0-5.0) (0.0-2.9) (0.0-5.6) (0.0-10.0) (0.0- 2.2) (0.2-2.2) (0.0-5.0) (0.0-0.6)
  1. N number of individuals analyzed, chr. number of chromosomes analyzed
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Genome Medicine

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