From: RNA interference approaches for treatment of HIV-1 infection
 | Function of target gene | Type of study | Reference(s) |
---|---|---|---|
HIV-1 gene targets | |||
   Gag | Proteolytic processing of the HIV-1 genome | Mouse | |
   Pol | Transcription | Mouse | [94] |
   env | Receptor binding and fusion | Phase I/II | |
   tat | Transcription or RNAi modulation | Phase 0 | [38] |
   rev | Reverse transcription, integration | Mouse | [140] |
   nef | Immune modulation | Mouse | |
   pol (integrase) | Integration | In vitro | |
   pol (reverse transcriptase) | Reverse transcription | In vitro | [176] |
  Promoter | Transcription | Mouse | [98] |
  Long terminal repeats | Genome expression | In vitro | |
Cellular targets | |||
  CCR5 | Receptor binding and fusion | Phase 0/phase I/II | [149] |
  CXCR4 | Receptor binding and fusion | In vitro | |
  CD4 | Receptor binding and fusion | In vitro | |
  LEDGF/p75 | Integration | In vitro | [179] |
  Importin-7 | Integration | In vitro | [180] |
  Chaperonin | Integration | In vitro | [181] |
  P-TEFb | Transcription | In vitro | [182] |
  Tat-SF1 | Transcription | In vitro | [87] |
  SPT5 | Transcription | In vitro | [183] |
  Cyclin T1 | Transcription | In vitro | [122] |
  DDX3 | Export | In vitro | [123] |
  SOCS1 | Trafficking or immune modulation | In vitro | [124] |
  TRBP | Immune modulation or RNAi pathway | In vitro | |
  TNPO3 | Nuclear entry of viral pre-integration complex | Mouse |