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Table 2 Potential RNAi targets for HIV-1 therapy

From: RNA interference approaches for treatment of HIV-1 infection

  Function of target gene Type of study Reference(s)
HIV-1 gene targets
   Gag Proteolytic processing of the HIV-1 genome Mouse [95, 168]
   Pol Transcription Mouse [94]
   env Receptor binding and fusion Phase I/II [169, 170]
   tat Transcription or RNAi modulation Phase 0 [38]
   rev Reverse transcription, integration Mouse [140]
   nef Immune modulation Mouse [92, 171174]
   pol (integrase) Integration In vitro [91, 175]
   pol (reverse transcriptase) Reverse transcription In vitro [176]
  Promoter Transcription Mouse [98]
  Long terminal repeats Genome expression In vitro [76, 93, 173]
Cellular targets
  CCR5 Receptor binding and fusion Phase 0/phase I/II [149]
  CXCR4 Receptor binding and fusion In vitro [120, 177]
  CD4 Receptor binding and fusion In vitro [150, 178]
  LEDGF/p75 Integration In vitro [179]
  Importin-7 Integration In vitro [180]
  Chaperonin Integration In vitro [181]
  P-TEFb Transcription In vitro [182]
  Tat-SF1 Transcription In vitro [87]
  SPT5 Transcription In vitro [183]
  Cyclin T1 Transcription In vitro [122]
  DDX3 Export In vitro [123]
  SOCS1 Trafficking or immune modulation In vitro [124]
  TRBP Immune modulation or RNAi pathway In vitro [75, 125]
  TNPO3 Nuclear entry of viral pre-integration complex Mouse [140, 151]