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Table 2 Potential RNAi targets for HIV-1 therapy

From: RNA interference approaches for treatment of HIV-1 infection

 

Function of target gene

Type of study

Reference(s)

HIV-1 gene targets

   Gag

Proteolytic processing of the HIV-1 genome

Mouse

[95, 168]

   Pol

Transcription

Mouse

[94]

   env

Receptor binding and fusion

Phase I/II

[169, 170]

   tat

Transcription or RNAi modulation

Phase 0

[38]

   rev

Reverse transcription, integration

Mouse

[140]

   nef

Immune modulation

Mouse

[92, 171–174]

   pol (integrase)

Integration

In vitro

[91, 175]

   pol (reverse transcriptase)

Reverse transcription

In vitro

[176]

  Promoter

Transcription

Mouse

[98]

  Long terminal repeats

Genome expression

In vitro

[76, 93, 173]

Cellular targets

  CCR5

Receptor binding and fusion

Phase 0/phase I/II

[149]

  CXCR4

Receptor binding and fusion

In vitro

[120, 177]

  CD4

Receptor binding and fusion

In vitro

[150, 178]

  LEDGF/p75

Integration

In vitro

[179]

  Importin-7

Integration

In vitro

[180]

  Chaperonin

Integration

In vitro

[181]

  P-TEFb

Transcription

In vitro

[182]

  Tat-SF1

Transcription

In vitro

[87]

  SPT5

Transcription

In vitro

[183]

  Cyclin T1

Transcription

In vitro

[122]

  DDX3

Export

In vitro

[123]

  SOCS1

Trafficking or immune modulation

In vitro

[124]

  TRBP

Immune modulation or RNAi pathway

In vitro

[75, 125]

  TNPO3

Nuclear entry of viral pre-integration complex

Mouse

[140, 151]