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Table 1 Summary statistics of demographic data for the eMERGE participants with PGRNSeq data by self-reported sex and race

From: Prospective participant selection and ranking to maximize actionable pharmacogenetic variants and discovery in the eMERGE Network

  Female Male Combined
  (N=546) (N=348) (N=894)
Self-Reported Race
American Indian orAlaska Native 2 %(9) 1 %(2) 1 %(11)
Asian 9 %(50) 5 %(19) 8 %(69)
Black or African American 5 %(29) 3 %(12) 5 %(41)
Native Hawaiian or otherPacific Islander 0 %(2) 0 %(0) 0 %(2)
Unknown 1 %(4) 5 %(16) 2 %(20)
White 83 %(452) 86 %(299) 84 %(751)
Ethnicity
No 95 %(520) 94 %(326) 95 %(846)
Yes 4 %(24) 2 %(6) 3 %(30)
Unknown 0 %(2) 5 %(16) 2 %(18)
Hx a of LQTS 0 %(0) 1 %(2) 0 %(2)
Hx of Hypertension 79 %(429) 80 %(279) 79 %(708)
Hx of Arrhythmia 48 %(264) 53 %(186) 50 %(450)
Hx of AF 7 %(38) 14 %(47) 10 %(85)
Hx of CHF 1 %(6) 3 %(12) 2 %(18)
Median LDL \(> 155\frac {mg}{dL}\) 9 %(50) 6 %(22) 8 %(72)
Median Triglyceride\(> 22\frac {mg}{dL}\) 6 %(33) 11 %(40) 8 %(73)
Median CK \( > 174\frac {IU}{L}\) 1 %(4) 7 %(23) 3 %(27)
Median TSH \(> 4\frac {\mu g}{dL}\) 6 %(34) 4 %(13) 5 %(47)
Median INR >1.5 7 %(36) 11 %(40) 9 %(76)
Total PGx Variants(total variants) 75.8±15.9 74.3±12.8 75.2±14.7
Coding PGx Variants(coding variants) 11.6±4.2 11.4±3.5 11.5±3.9
Group Health PGx Variants (gh variants) 40.0±9.6 38.5±8.7 39.4±9.3
  1. The continuous variables total variants, coding variants, and gh variants are presented in terms of mean and ± standard deviation
  2. aHx = History found in the EHR