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Fig. 8 | Genome Medicine

Fig. 8

From: Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration

Fig. 8

Genes associated with the RPE wound response are over-represented among those genes with altered expression in advanced AMD. Genes with two-fold increased or decreased expression as a function of passage were cross-referenced with the Up- and Down- RPE-choroid and retina AMD-associated gene sets reported by Newman et al. [14]. The charts depict the significance (−log(P value), Fishers’s exact test) of the overlap relative to the null hypothesis for the RPE-choroid (a) and retina (b) gene sets. Combined refers to the gene set resulting from the pooled analysis of the macular and extramacular samples

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Genome Medicine

ISSN: 1756-994X

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