Fig. 9
AMD risk-associated genes with altered expression in late-passage RPE. Of 63 genes with reported association with altered risk for AMD that were evaluated, 50 were found to be expressed by cultured RPE. Of the expressed genes 75 % were found to have two-fold or greater changes in expression as a function of passage based on the microarray analysis (one-way ANOVA P value ≤0.05, n = 3). Shown are the log2 transformed P5:P0 expression ratios for genes whose association has been replicated in multiple studies or identified in recent large cohort genome wide association or single loci analysis. The corresponding citations (Ref.) are indicated on the right