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Table 5 Detailed clinical information of 47 MYC-rearranged DLBCL cases

From: Transferring genomics to the clinic: distinguishing Burkitt and diffuse large B cell lymphomas

Sample IDa BL probb Treatmentc Survival (years)/responsed BCL2, BCL6 rearrangement
13 cases with MYC-rearrangement classified as BL by BDC
HMRN_52_v3_old 0.52 R-CHOP Alive (4.46) BCL2 rearranged
HMRN_30_v4_new 0.617 R-CHOP Alive (1.9) BCL2, BCL6 rearranged
RCH_125_v4_new 0.75 R-CHOP Complete remission BCL2, BCL6 rearranged
RCH_93_v4_new 0.665 R-CHOP Persistent disease BCL2 rearranged
HMRN_64_v4_old 0.716 R-CHOP Died (2.14) BCL2 rearranged
LY_43_v4_rep 0.662 R-CHOP Died (0.45) BCL2, BCL6 rearranged
HMRN_107_v4_old 0.745 R-CHOP Died (0.63) BCL2 rearranged
HMRN_34_v4_new 0.738 R-CHOP Died (0.35) BCL2 rearranged
HMRN_8_v4_old 0.561 R-CHOP Died (0.95) BCL2 rearranged
HMRN_74_v4_old 0.552 R-CHOP Died (6.19) BCL2 rearranged
LY_3_v4_new 0.777 CODOX-M/IVAC Died (0.08) BCL2 rearranged, BCL6 normal
HMRN_45_v4_rep 0.674 Unknown Unknown BCL2 rearranged
HMRN_56_v4_rep_2 0.711 Unknown Unknown BCL2, BCL6 rearranged
34 cases with MYC-rearrangement classified as DLBCL by BDC
HMRN_49_v4_new 0.029 R-CHOP Alive (1.08) BCL6 rearranged
HMRN_47_v4_old 0.017 R-CHOP Alive (6.40) BCL6 rearranged
HMRN_112_v4_old 0.07 R-CHOP Alive (6.31) BCL6 rearranged
HMRN_52_v4_new 0.126 R-CHOP Alive (1.22) BCL2 amplified
HMRN_35_v4_new 0.168 R-CHOP Alive (1.25) BCL2 rearranged
HMRN_37_v4_new 0.008 R-CHOP Alive (4.59) BCL2 rearranged
HMRN_53_v4_old 0.032 R-CHOP Alive (4.85) BCL2 rearranged
HMRN_55_v4_new 0.136 R-CHOP Alive (3.9) BCL2 rearranged
HMRN_49_v4_old 0.01 R-CHOP Alive (6.06) BCL2 rearranged
HMRN_132_v3_old 0.023 R-CHOP Alive (6.86) BCL2, BCL6 normal
LY_35_v4_rep 0.016 R-CHOP Alive (1.55) BCL2 normal, BCL6 rearranged
LY_40_v4_rep 0.037 R-CHOP Alive (1.59) BCL2 normal, BCL6 rearranged
RCH_134_v4_new 0.086 R-CHOP Complete remission BCL6 rearranged
RCH_133_v4_new 0.148 R-CHOP Complete remission BCL2 rearranged
RCH_122_v4_new 0.19 R-CHOP Complete remission BCL2 rearranged
RCH_76_v4_new 0.162 R-CHOP Complete remission BCL2, BCL6 normal
RCH_120_v4_new 0.375 R-CHOP Complete remission BCL2, BCL6 normal
RCH_109_v4_new 0.008 R-CHOP Persistent disease (died) BCL6 rearranged
LY_37_v4_rep 0.071 R-CHOP Died (0.95) BCL2 rearranged, BCL6 normal
LY_17_v4_rep 0.15 R-CHOP Died (1.04) BCL2, BCL6 normal
HMRN_46_v4_rep 0.245 R-CHOP Died (0.49) BCL2 rearranged
HMRN_104_v3_old 0.009 R-CHOP Died (0.39) BCL2, BCL6 normal
HMRN_76_v4_old 0.195 R-CHOP Died (0.66) BCL2, BCL6 normal
HMRN_42_v4_new 0.088 R-CHOP Died (1.81) BCL2, BCL6 normal
HMRN_129_v4_old 0.02 R-CHOP Died (0.37) BCL2, BCL6 normal
LY_21_v4_rep 0.5 CODOX-M/IVAC Died (0.14) BCL2 rearranged, BCL6 normal
HMRN_172_v4_old 0.034 No active treatment Died (0.02) BCL2 rearranged
HMRN_48_v4_rep 0.015 No active treatment Died (1.8) BCL2 rearranged
HMRN_5_v3_old 0.082 No active treatment Died (0.18) BCL6 rearranged, BCL2 amplified
HMRN_23_v4_new 0.015 No active treatment Died (0.09) BCL2, BCL6 normal
HMRN_44_v4_rep 0.313 Died before treatment Died (0.04) BCL2 rearranged
HMRN_54_v4_rep 0.216 Died before treatment Died (0.03) BCL2 rearranged
HMRN_70_v4_rep 0.111 R-CHOP Unknown BCL6 rearranged
HMRN_18_v4_new 0.093 Unknown Unknown BCL2, BCL6 rearranged
  1. aSamples are collected from two clinical trails as well as local cases in the Haematological Malignancy Diagnostic Service (HMDS; St James Hospital, Leeds). Sample IDs starting with RCH are records from R-CHOP-treated trials and those starting with LY [28] are records from a dose-modified CODOX-M/IVAC trial. The rest of the samples starting with HMRN are local patients from the HMDS database. Samples labelled with the _old suffix are cases submitted to the Gene Expression Omnibus (GEO) in previous studies, and those labeled with the _new suffix are cases not in the GEO database yet
  2. bBL prob is the Burkitt lymphoma probability generated by BDC (Burkitt lymphoma and diffuse large B cell lymphoma classifier developed in our work)
  3. cR-CHOP is usually used to treat DLBCL; CODOX-M/IVAC is a treatment usually for BL or BL-like patients
  4. dIn R-CHOP trials, all patients are evaluated with treatment response and this is used in the study