Table 5 Detailed clinical information of 47 MYC-rearranged DLBCL cases
From: Transferring genomics to the clinic: distinguishing Burkitt and diffuse large B cell lymphomas
Sample IDa | BL probb | Treatmentc | Survival (years)/responsed | BCL2, BCL6 rearrangement |
|---|---|---|---|---|
13 cases with MYC-rearrangement classified as BL by BDC | ||||
HMRN_52_v3_old | 0.52 | R-CHOP | Alive (4.46) | BCL2 rearranged |
HMRN_30_v4_new | 0.617 | R-CHOP | Alive (1.9) | BCL2, BCL6 rearranged |
RCH_125_v4_new | 0.75 | R-CHOP | Complete remission | BCL2, BCL6 rearranged |
RCH_93_v4_new | 0.665 | R-CHOP | Persistent disease | BCL2 rearranged |
HMRN_64_v4_old | 0.716 | R-CHOP | Died (2.14) | BCL2 rearranged |
LY_43_v4_rep | 0.662 | R-CHOP | Died (0.45) | BCL2, BCL6 rearranged |
HMRN_107_v4_old | 0.745 | R-CHOP | Died (0.63) | BCL2 rearranged |
HMRN_34_v4_new | 0.738 | R-CHOP | Died (0.35) | BCL2 rearranged |
HMRN_8_v4_old | 0.561 | R-CHOP | Died (0.95) | BCL2 rearranged |
HMRN_74_v4_old | 0.552 | R-CHOP | Died (6.19) | BCL2 rearranged |
LY_3_v4_new | 0.777 | CODOX-M/IVAC | Died (0.08) | BCL2 rearranged, BCL6 normal |
HMRN_45_v4_rep | 0.674 | Unknown | Unknown | BCL2 rearranged |
HMRN_56_v4_rep_2 | 0.711 | Unknown | Unknown | BCL2, BCL6 rearranged |
34 cases with MYC-rearrangement classified as DLBCL by BDC | ||||
HMRN_49_v4_new | 0.029 | R-CHOP | Alive (1.08) | BCL6 rearranged |
HMRN_47_v4_old | 0.017 | R-CHOP | Alive (6.40) | BCL6 rearranged |
HMRN_112_v4_old | 0.07 | R-CHOP | Alive (6.31) | BCL6 rearranged |
HMRN_52_v4_new | 0.126 | R-CHOP | Alive (1.22) | BCL2 amplified |
HMRN_35_v4_new | 0.168 | R-CHOP | Alive (1.25) | BCL2 rearranged |
HMRN_37_v4_new | 0.008 | R-CHOP | Alive (4.59) | BCL2 rearranged |
HMRN_53_v4_old | 0.032 | R-CHOP | Alive (4.85) | BCL2 rearranged |
HMRN_55_v4_new | 0.136 | R-CHOP | Alive (3.9) | BCL2 rearranged |
HMRN_49_v4_old | 0.01 | R-CHOP | Alive (6.06) | BCL2 rearranged |
HMRN_132_v3_old | 0.023 | R-CHOP | Alive (6.86) | BCL2, BCL6 normal |
LY_35_v4_rep | 0.016 | R-CHOP | Alive (1.55) | BCL2 normal, BCL6 rearranged |
LY_40_v4_rep | 0.037 | R-CHOP | Alive (1.59) | BCL2 normal, BCL6 rearranged |
RCH_134_v4_new | 0.086 | R-CHOP | Complete remission | BCL6 rearranged |
RCH_133_v4_new | 0.148 | R-CHOP | Complete remission | BCL2 rearranged |
RCH_122_v4_new | 0.19 | R-CHOP | Complete remission | BCL2 rearranged |
RCH_76_v4_new | 0.162 | R-CHOP | Complete remission | BCL2, BCL6 normal |
RCH_120_v4_new | 0.375 | R-CHOP | Complete remission | BCL2, BCL6 normal |
RCH_109_v4_new | 0.008 | R-CHOP | Persistent disease (died) | BCL6 rearranged |
LY_37_v4_rep | 0.071 | R-CHOP | Died (0.95) | BCL2 rearranged, BCL6 normal |
LY_17_v4_rep | 0.15 | R-CHOP | Died (1.04) | BCL2, BCL6 normal |
HMRN_46_v4_rep | 0.245 | R-CHOP | Died (0.49) | BCL2 rearranged |
HMRN_104_v3_old | 0.009 | R-CHOP | Died (0.39) | BCL2, BCL6 normal |
HMRN_76_v4_old | 0.195 | R-CHOP | Died (0.66) | BCL2, BCL6 normal |
HMRN_42_v4_new | 0.088 | R-CHOP | Died (1.81) | BCL2, BCL6 normal |
HMRN_129_v4_old | 0.02 | R-CHOP | Died (0.37) | BCL2, BCL6 normal |
LY_21_v4_rep | 0.5 | CODOX-M/IVAC | Died (0.14) | BCL2 rearranged, BCL6 normal |
HMRN_172_v4_old | 0.034 | No active treatment | Died (0.02) | BCL2 rearranged |
HMRN_48_v4_rep | 0.015 | No active treatment | Died (1.8) | BCL2 rearranged |
HMRN_5_v3_old | 0.082 | No active treatment | Died (0.18) | BCL6 rearranged, BCL2 amplified |
HMRN_23_v4_new | 0.015 | No active treatment | Died (0.09) | BCL2, BCL6 normal |
HMRN_44_v4_rep | 0.313 | Died before treatment | Died (0.04) | BCL2 rearranged |
HMRN_54_v4_rep | 0.216 | Died before treatment | Died (0.03) | BCL2 rearranged |
HMRN_70_v4_rep | 0.111 | R-CHOP | Unknown | BCL6 rearranged |
HMRN_18_v4_new | 0.093 | Unknown | Unknown | BCL2, BCL6 rearranged |