Fig. 5
From: Inferring pathway dysregulation in cancers from multiple types of omic data
Summary of gene expression and somatic mutation differences between uterine serous (USC) and uterine endometrioid carcinomas (UEC) for the MYC pathway. Genes upregulated in USC were MYC (P = 3.3 × 10−8), TRRAP (P = 3.8 × 10−4), PI3KCA (P = 1.4 × 10−10), MAPK3 (P = 5.8 × 10−5), CAD (P = 6.9 × 10−9), ODC1 (P = 1.9 × 10−11), CKS1B (P = 9.2 × 10−14), SKP2 (P = 3.0 × 10−3), CDKN1A (P = 6.8 × 10−20), CCNE1 (P = 2.5 × 10−18), and CDK2 (P = 2.0 × 10−5). TP53 (P = 2.5 × 10−3) and FBXW7 (P = 3.8 × 10−4) were upregulated and somatically mutated. CDKN1A (P = 6.8 × 10−20) and TAF9 (5.9 × 10−13) were down in USC. This suggests upregulation of the MYC pathway in USC. A Wilcoxon rank test was used for RNA-Sequencing, and a Fisher’s Exact test for somatic mutations