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Table 2 Comparison of CSN and current nomenclature for exonic base substitutions

From: CSN and CAVA: variant annotation tools for rapid, robust next-generation sequencing analysis in the clinical setting

CSN Current nomenclaturea
  Nucleotide Amino acid
c.1040A>G_p.Gln347Arg c.1040A>G p.Gln347Arg
c.1911T>C_p.= c.1911T>C p.Gly637Gly
c.3264T>C_p.= c.3264T>C p.Pro1088Pro
c.3515C>T_p.Ser1172Leu c.3515C>T p.Ser1172Leu
c.3516G>A_p.= c.3516G>A p.Ser1172Ser
c.5682C>G_p.Tyr1894X c.5682C>G p.Tyr1894Ter
c.5855T>A_p.Leu1952X c.5855T>A p.Leu1952Ter
c.6131G>T_p.Gly2044Val c.6131G>T p.Gly2044Val
c.6675A>G_p.= c.6675A>G p.Thr2225Thr
c.7558C>T_p.Arg2520X c.7558C>T p.Arg2520Ter
c.8182G>A_p.Val2728Ile c.8182G>A p.Val2728Ile
c.9976A>T_p.Lys3326X c.9976A>T p.Lys3326Ter
  1. CSN allows easy visual discrimination between the different classes of exonic base substitutions with ‘=’ denoting a synonymous variant, ‘X’ denoting a stop-gain variant and the three letter code of the new amino acid denoting a nonsynonymous variant. CSN includes both the nucleotide and amino acid level descriptions to give a single, unique identifier for each variant.
  2. aThe current nomenclature given is one of several different notation systems currently in use