Fig. 3
From: Achieving high-sensitivity for clinical applications using augmented exome sequencing
Relationship between the percentages of MIG exons ‘finished’ as the coverage stringency varies. The left graph shows the percentage of MIG exons (y-axis) with ≥90.0-100.0 % of bases covered at ≥20× depth (x-axis) among different platforms using data obtained on NA12878. The right graph shows the percentage of finished exons (y-axis) with 100.0 % base coverage as the local coverage depth varies ≥10-20× (x-axis). At higher coverage stringencies, ACE finishes more exons than other WGS or WES assays in regions defined as the entire exon (solid curves) or only the subset of coding-regions (circles). ACE and conventional WES data are normalized to 100× mean target coverage
