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Fig. 3 | Genome Medicine

Fig. 3

From: Achieving high-sensitivity for clinical applications using augmented exome sequencing

Fig. 3

Relationship between the percentages of MIG exons ‘finished’ as the coverage stringency varies. The left graph shows the percentage of MIG exons (y-axis) with ≥90.0-100.0 % of bases covered at ≥20× depth (x-axis) among different platforms using data obtained on NA12878. The right graph shows the percentage of finished exons (y-axis) with 100.0 % base coverage as the local coverage depth varies ≥10-20× (x-axis). At higher coverage stringencies, ACE finishes more exons than other WGS or WES assays in regions defined as the entire exon (solid curves) or only the subset of coding-regions (circles). ACE and conventional WES data are normalized to 100× mean target coverage

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