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Fig. 1 | Genome Medicine

Fig. 1

From: Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance

Fig. 1

Shifts in mRNA and protein abundance show modest correlation in the comparison between psoriasis lesions and uninvolved skin (r s  = 0.40). a Correlation between fold changes (PP/PN) calculated by RNA-seq and LC-MS/MS (2172 mRNA–protein pairs). The dashed red line is a least-squares regression estimate and the yellow ellipse outlines the middle 50 % of data points nearest to the bivariate mean (Mahalanobis distance). b Pearson residuals. Each mRNA–protein pair was assigned to one of four groups (see legend). Residuals reflect the degree to which counts in each group (n) differ from those expected under the null hypothesis (i.e., random association between changes in mRNA and protein abundance). Positive residuals indicate over-abundance of mRNA–protein pairs, while negative residuals indicate under-abundance. c mRNA–protein pairs showing the strongest increase in mRNA and protein abundance. d mRNA–protein pairs showing the strongest decrease in mRNA and protein abundance. e mRNA–protein pairs with discordant changes in mRNA and protein abundance (PP-decreased mRNA; PP-increased protein). f mRNA–protein pairs with discordant changes in mRNA and protein abundance (PP-increased mRNA; PP-decreased protein). In (c–f), mRNA–protein pairs were chosen based upon the strength of p values derived from tests for differential mRNA and protein abundance (PP versus PN skin; yellow bars indicate DEGs/DEPs). Average FPKM or NSAF is listed at the base of each bar. These values were calculated for both PP and PN skin, respectively, and the higher of the two values is listed

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