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Fig. 2 | Genome Medicine

Fig. 2

From: Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance

Fig. 2

Translation machinery and ribosomal proteins are elevated in psoriasis lesions despite decreased mRNA levels. a GO biological process (BP) terms enriched among genes associated with 124 mRNA–protein pairs with discordant PP versus PN changes (i.e., PP-decreased mRNA, p < 0.10; PP-increased protein, p < 0.10). GO BP terms were enriched with respect to a background set of 2087 genes with detectable expression (RNA-seq) and associated with a protein identified by LC-MS/MS. b Genes and proteins associated with the “translational elongation” GO BP term. Fold-changes (PP/PN) and p values are listed in the right margin of each panel (n = 14 patients; red font indicates DEPs)

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