Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance

Fig. 4

Proteins expressed in immunocytes and fetal tissues are elevated in psoriasis lesions (human proteome map). a Human proteome map cell types ranked by the correlation between cell type-specific expression and LC-MS/MS-estimated fold-change (PP/PN) (1764 proteins; magenta font indicates p < 0.05). b Association between B-cell-specific expression and fold change (PP/PN). B-cell-specific expression is quantified based upon the ratio of SpC values between B cells and all other cell types (B cells/Other, horizontal axis). The dashed red line is the least-square regression estimate and the yellow ellipse outlines the 50 % of proteins nearest to the bivariate mean (Mahalanobis distance). c Human proteome map cell types ranked according to how strongly the 12 best signature proteins for each cell type are enriched among proteins with elevated abundance in PP skin (magenta font indicates p < 0.05). d Enrichment of fetal ovary signature proteins among PP-increased proteins. The 1764 proteins were ranked in descending order from left to right based upon the LC-MS/MS-estimated fold change (PP/PN). The figure shows cumulative overlap between this ranked list of proteins and the 12 fetal ovary signature proteins (vertical axis). The ranking of each signature protein is indicated (yellow hash marks, top). Enrichment of the 12 proteins among PP-increased proteins is demonstrated by the positive area between the cumulative overlap curve and diagonal. e Fetal ovary signature proteins and their relative abundance across human proteome map cell types (heatmap of normalized SpC values). The LC-MS/MS-estimated fold change (PP/PN) is shown for each protein (right; yellow bars indicates DEPs). Average NSAF in PP samples is listed at the base of each bar

Back to article page