Fig. 7

Psoriasis-specific and non-specific DEGPs have divergent responses to differentiation-associated stimuli (stratified GSEA). a Non-cytokine treatments that differentially impact expression of psoriasis-specific and non-specific DEGPs (cultured KCs; *HaCaT cells; **reconstituted epidermis). The 153 PP-increased DEGPs were ranked according to the percentage of skin diseases in which the mRNA’s expression was correspondingly increased. Sliding DEGP windows (10 DEGPs/window) were analyzed to assess enrichment of DEGPs among genes induced by each treatment (red indicates windows with induced DEGPs; blue indicates windows with repressed DEGPs). Robust regression was used to quantify the left-to-right trend in enrichment statistics, and the listed experiments were associated with the most negative (top) or positive (bottom) trends (out of 170 experiments screened). Enrichment statistics and p values were also calculated using the complete set of 153 DEGPs (right margin; red/blue font indicates FDR < 0.05, Wilcoxon rank sum test). b The 20 most psoriasis-specific PP-increased DEGPs are marginally enriched among genes induced by dexamethasone (p = 0.116; 48 h treatment, GSE26487). Genes were ranked along the horizontal axis according to how strongly they are induced by dexamethasone (left/red, dexamethasone-induced; right/blue, dexamethasone-repressed). The figure shows cumulative overlap between the 20 psoriasis-specific DEGPs and this ranked gene list. c The 20 most non-specific PP-increased DEGPs are enriched among genes repressed by dexamethasone (p < 0.001; 48 h treatment, GSE26487). Genes were ranked along the horizontal axis according to how strongly they are induced by dexamethasone (left/red, dexamethasone-induced; right/blue, dexamethasone-repressed). The figure shows cumulative overlap between the 25 non-specific DEGPs and this ranked gene list