Fig. 1

Partitioning of omic profiles among individuals. a Each histogram shows the density of the percent variation for each measure (feature) in the indicated omic class that is among individuals, based on three biological samples taken at 6 month intervals for 12 people. Pearson correlation R-squared values were obtained from standardized trait measures (phenome, transcriptome or miRNAome), or the beta values (methylome, since these are not normally distributed). b Two way hierarchical clustering of the first 10 principal components of the 36 samples, showing strong conservation of the summary measures within individuals across replicates, with the exception of the miRNAome. The ten columns in each panel correspond to the first 10 PC, blue negative, red positive values