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Fig. 4 | Genome Medicine

Fig. 4

From: Omic personality: implications of stable transcript and methylation profiles for personalized medicine

Fig. 4

Extreme deviations in gene expression or methylation. a Heat map of all genes significantly differentially expressed in each individual relative to the other 11 individuals by ANOVA. Each of the three biological replicates for each individual clustered adjacent to one another, and groups of transcripts with elevated expression (red) or reduced expression (blue) are clearly visible. In some cases, there were reciprocal patterns for the most extreme sets, for example Aa and Ad or Mk and Ml. b Heat map of all peak CpG where one individual was at least 0.3 beta units deviant from the sample average. Each individual had a unique set of hypomethylated sites (blue, with an excess in the African American females Aa, Ab, Ac, and Ad), with relatively few hypermethylated sites, and a large number of sites where the distribution of beta values was bimodal with multiple red or blue individuals

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