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Table 2 Associations between diseases and cell types of particular classes. The table shows the proportion of cell types in a class identified as associated with a disease class

From: Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types

Disease class Cell-type class GSC GSO Text-mining
Cardiovascular diseases Cardiovascular cells 4.7 % (5/107) 7.2 % (7/97) 27.3 % (50/183)
Cardiovascular diseases Immune system cells 42.1 % (45/107) 36.1 % (35/97) 19.1 % (35/183)
Immune system diseases Immune system cells 87.8 % (129/146) 86.5 % (109/126) 58.4 % (118/202)
Mental disorders Neural cells 51.6 % (16/31) 38.7 % (12/31) 66.7 % (12/18)
  1. The MeSH database and cell ontology were used to identify diseases and cell types belonging to each class. A disease and cell type were said to belong to a class if they were descendants of the following terms: cardiovascular diseases (C14), cardiovascular cells (CL:0002139 and CL:0002494), immune system diseases (C20), immune system cells (CL:0000738), mental disorders (F03) and neural cells (CL:0002319). An FDR cutoff of 10 % was applied to the results of each method to produce sets of disease–cell-type associations
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Genome Medicine

ISSN: 1756-994X

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