Disease class | Cell-type class | GSC | GSO | Text-mining |
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Cardiovascular diseases | Cardiovascular cells | 4.7 % (5/107) | 7.2 % (7/97) | 27.3 % (50/183) |
Cardiovascular diseases | Immune system cells | 42.1 % (45/107) | 36.1 % (35/97) | 19.1 % (35/183) |
Immune system diseases | Immune system cells | 87.8 % (129/146) | 86.5 % (109/126) | 58.4 % (118/202) |
Mental disorders | Neural cells | 51.6 % (16/31) | 38.7 % (12/31) | 66.7 % (12/18) |
- The MeSH database and cell ontology were used to identify diseases and cell types belonging to each class. A disease and cell type were said to belong to a class if they were descendants of the following terms: cardiovascular diseases (C14), cardiovascular cells (CL:0002139 and CL:0002494), immune system diseases (C20), immune system cells (CL:0000738), mental disorders (F03) and neural cells (CL:0002319). An FDR cutoff of 10 % was applied to the results of each method to produce sets of disease–cell-type associations