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Table 6 Functional annotation for genes associated with the 13 sites that were successfully replicated

From: DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection

Category

Term

Genes

P-value*

SP_PIR_KEYWORDS

Polymorphism

COPA , KIAA0494 , EPX , ZNF862 , PRG2 , ASCC1 , ZFPM1

0.0145

SP_PIR_KEYWORDS

Eosinophil

EPX , PRG2

0.0087

KEGG_PATHWAY

Asthma

EPX , PRG2

0.0005

UP_SEQ_FEATURE

Sequence variant

COPA, KIAA0494, EPX, ZNF862, PRG2, ASCC1, ZFPM1

0.1365

GOTERM_MF_FAT

GO:0005509 Calcium ion binding

COPA, KIAA0494, PVALB, EPX

0.1807

SP_PIR_KEYWORDS

Nitration

EPX, PRG2

0.1539

SP_PIR_KEYWORDS

Alternative splicing

LSM14B, COPA, ZNF862, ATL3, ASCC1

0.3382

GOTERM_MF_FAT

GO:0046872 Metal ion binding

COPA, KIAA0494, PVALB, EPX, ZNF862, ZFPM1

0.3749

GOTERM_BP_FAT

GO:0048193 Golgi vesicle transport

COPA, ATL3

0.8360

GOTERM_MF_FAT

GO:0043169 Cation binding

COPA, KIAA0494, PVALB, EPX, ZNF862, ZFPM1

0.2826

GOTERM_MF_FAT

GO:0043167 Ion binding

COPA, KIAA0494, PVALB, EPX, ZNF862, ZFPM1

0.2291

SP_PIR_KEYWORDS

Calcium

KIAA0494, PVALB, EPX

0.3469

SP_PIR_KEYWORDS

Phosphoprotein

LSM14B, COPA, KIAA0494, PVALB, ATL3, ZFPM1

0.2989

SP_PIR_KEYWORDS

Cytoplasmic vesicle

COPA, PRG2

0.5085

UP_SEQ_FEATURE

Splice variant

LSM14B, COPA, ZNF862, ATL3, ASCC1

0.9270

UP_SEQ_FEATURE

Domain:EF-hand 1

KIAA0494, PVALB

0.8342

UP_SEQ_FEATURE

Domain:EF-hand 2

KIAA0494, PVALB

0.7430

INTERPRO

IPR018249: EF-HAND 2

KIAA0494, PVALB

0.9655

GOTERM_BP_FAT

GO:0006350 Transcription

ZNF862, ASCC1, ZFPM1

0.9478

INTERPRO

IPR018247: EF-HAND 1

KIAA0494, PVALB

0.8227

  1. Statistically significant DAVID functional annotation and pathway results are in bold
  2. * P-values corrected for multiple testing via Benjamini–Hochberg method
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Genome Medicine

ISSN: 1756-994X

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