Fig. 5

The polarized immune response is a dominant feature across DLBCL, independent of COO class. a The incidences of individual cases across all data sets (note GSE10846 is subdivided into CHOP and R-CHOP treated components) ranked according to polarized immune response score. The top and bottom 25 cases for each data set are illustrated with colour coding for COO class shown in the top bar (yellow ABC, blue GCB, green unclassified), class confidence assigned during classification shown in the middle bar (blue low confidence to red high confidence), and polarized immune response score shown in the bottom bar (blue low polarized immune response score to red high polarized immune response score). b Complete results for data sets GSE10846 R-CHOP and GSE31312, showing all cases ranked by polarized immune response score. Each heatmap displays class assignment, classification confidence and polarized immune response score summary as in (a) followed by COO-classifier gene expression (yellow and blue bars), the 16 genes of the polarized immune response score (green bar), and the extended set of COO-unclassified meta-profile genes (black bar). A corresponding high-resolution figure comprising equivalent representation for all data sets is provided in Additional file 13