Fig. 5

Temporal characteristics of time-based networks showing active disease (AD) patients (top panel, A) and inactive disease (ID) patients (lower panel, B), where the y-axis denotes the value of the corresponding topological measure and the x-axis denotes the four different timestamps (baseline, 4 months, 6 months, and 12 months). a Change of the average between-ness measure throughout the timestamps. b Change of the average clustering coefficient measure throughout the timestamps. c Change of the average closeness measure through the timestamps