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Fig. 6 | Genome Medicine

Fig. 6

From: Dynamic tracking of functional gene modules in treated juvenile idiopathic arthritis

Fig. 6

Evolutionary events detected from strategy-based analysis with the threshold set to 0.12. Stages refer to those shown in Fig. 4a. The 50 gene clusters are aligned vertically at each timestamp. In this figure: a The evolutionary events detected in non-responders where the functional modules detected at stages 1, 2a, and 3 interact with each other; b The evolutionary events detected in responders where the functional module detected at stages 1, 2b, and 3 interact with each other. c Pie graphs of evolutionary event calculation for each non-responders (top) and responders (bottom), where the percent of five evolutionary events at a certain time gap are shown. Note the relative paucity of ‘continue’ events in either responders or non-responders, indicating that treatment is associated with significant re-ordering of network structures regardless of therapeutic response

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